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Why these two get studied together The short answer is that the preclinical literature on each peptide individually points at overlapping but distinct elements of the wound-repair toolkit: BPC-157 has been associated with angiogenesis and growth-factor signaling, while thymosin beta-4 fragments have been associated with cell migration

Mercimek-Mahmutoglu et al 2014

One posited mechanism is the activation of phospholipase C (PLC), which, according to some researchers, might subsequently facilitate the release of inositol triphosphate (IP3) and diacylglycerol (DAG)

Subsequent small studies have produced inconsistent findings