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A long-acting release form of exenatide (exenatide ER, Bydureon) was approved by the FDA in 2012, becoming the first once-weekly injection of a GLP-1RA for adults with T2DM [ Table 2 ]
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In reality, up to 70% of patients stop GLP-1 treatment within a year most often due to: High cost (GLP-1s can cost $1,000+ per month without insurance) Loss of insurance coverage for weight loss treatment Side effects such as nausea, diarrhea, constipation, or fatigue A Misconceptions some patients stop once they lose initial weight, believing they no longer need the medication 2
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