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Decreased GSH levels have been shown to activate NF-kB, further impairing mitochondrial function and creating a vicious cycle
To induce intracellular GSH depletion, cells were incubated in Cys 2 -free medium or with BSO (1000 M) treatment or erastin (10 M) treatment
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Therefore it is essential to investigate the effect of GSH depletion on RPE cells to further elucidate the potentially involved mechanisms
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