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This warning is not based on human epidemiology alone but largely originates from rodent toxicology studies , where GLP-1 receptor activation led to: Increased calcitonin secretion C-cell hyperplasia C-cell adenomas and carcinomas in rats/mice These findings have been consistently observed across multiple GLP-1 receptor agonists

This means sticking to a balanced diet and regular exercise routinenot anything extreme, just consistent healthy habits

Activities that engage the core and promote general movement are beneficial

More recently, however, an animal study based on a tandem stenosis mouse model showed the ability of SGLT2is to stabilize atherosclerotic plaques, with increased fibrosis, augmented collagen accumulation, and significant upregulation of the expression of vasculoprotective NADPH oxidase 4 [18]