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Compared to control rats, MTX treatment resulted in substantial increases in AST, ALT, and ALP activities, as well as in the concentration of cholesterol, triacylglycerides, and LDL-cholesterol, and a reduction in the serum concentration of HDL-cholesterol

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A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric no-dependent and gut-brain axis mechanism