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They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects

This provides a biological basis for considering whether pharmacological GLP-1 therapies, which achieve much higher systemic levels, could also reach the joint and potentially have local effects. Additionally, scientists found that the level of GLP-1 hormone in the synovial fluid is directly tied to the levels in the blood of arthritis patients