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Study design: Real-world data, real impact Using a target trial emulation framework, researchers analyzed Truveta Data and compared adults with AUD and either type 2 diabetes or obesity who started a GLP-1 RA to similar individuals starting alternative medications

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But retatrutide may be even more effective , for several reasons: Glucagon receptor activation promotes hepatic fat oxidation Reduces liver fat accumulation more robustly Improves liver enzyme levels (ALT, AST) In a subgroup analysis of the retatrutide Phase 2 trial: Patients with suspected NAFLD showed a 70%+ reduction in liver fat content , measured by MRI-PDFF These effects surpassed the reductions seen with tirzepatide and semaglutide in comparable studies Another study showed that 93% of patients on the highest dose of retatrutide had 100% resolution of fatty liver