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In cultured cells, GLP-1 mediates its effects through G proteins linked to adenylyl cyclase, resulting in increased intracellular circulating adenosine monophosphate and activation of protein kinase A (PKA) [17]
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By the second week of the study both groups showed an improvement in their symptoms a two-point improvement in the disability scale used (Guys neurological disability scale or GNDS) a wider assessment of disability than the more often used EDSS (Expanded Disability Status Scale)
Radiographically, remodeling at the surgical site was apparent, with bone exhibiting the normal trabecular pattern ( Fig
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