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Constipation is also common, resulting from the combined effects of the following: age-related slowing of gastrointestinal transit lower fluid intake reduced physical activity GLP-1-induced delayed gastric emptying Increasing soluble fiber intake through foods such as oats, legumes, chia seeds, fruit, or psyllium supplementation may help promote bowel regularity, but fiber should be increased gradually and paired with adequate hydration to avoid worsening symptoms
NAD+: NMN and NR supplementation have shown favorable safety profiles in multiple human trials at doses up to 1200 mg/day
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