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Indeed, while SCFAs infused into the intestinal lumen activate VANs projecting from the gut 12 and intraperitoneal SCFA injection suppressed food intake through vagal afferent signaling, butyrate treatment directly activates isolated nodose ganglion neurons from mice 12

Notably, in high-quality large RCTs, tirzepatide demonstrated greater effectiveness than GLP-1R mono agonists in reducing serum glucose, fat mass, and body weight