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"Nascobal (Cyanocobalamin, USP) Nasal Spray 500 mcg/spray 0.125 mL Rx only" (PDF)
Anti-Aging Potential: NAD+ elevation activates sirtuins, which combat cellular aging and inflammation
The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction
I'm looking for better research on the process of mobilization of B12 from liver stores - in some textbooks it has been described as "not well understood" so it seems to me this is an open question
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