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In the ligand-bound bovine cryo-EM structures of MRP1 (Johnson and Chen, 2017
The active ingredient, semaglutide, is FDA-approved in branded products (Wegovy, Ozempic), but a compounded preparation is not itself an FDA-approved drug
5.2.2 Impact of comorbidities commonly seen in patients with T2D on oral semaglutide absorption Upper GI disease and hepatic and renal impairment are common comorbidities in patients with T2D that may influence the pharmacokinetics of antidiabetes drugs [68, 69]
It can be a useful, informal indicator of bioactivity
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