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The methodological limitations identified, including the small number of clinical trials, reduced sample sizes, heterogeneity in interventions, ascent protocols and lack PK/PD analysis limit the strength of the available evidence

Topical collagen also holds some merit in skincare routines alongside tretinoin and can be used simultaneously without any worry of interaction

However, if you find that taking supplements on an empty stomach triggers your reflux, you can take it with a light, non-triggering snack

Natural alternatives include vitamin C serums, kojic acid from rice bran, arbutin from bearberry plants, and liquorice extract