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Quick Takeaways Ipamorelin creates a more physiologic and pulsatile GH release, with fewer systemic hormonal disruptions MK-677 reliably elevates GH and IGF-1, improves sleep, and increases lean mass at the expense of hammering insulin sensitivity Neither compound is FDA-approved for anti-aging optimization or physique enhancement
If you know exactly what to expect and when week by week you are far more likely to stay on the medication long enough to reach the therapeutic dose where real weight loss happens
Azmi NASM et al
The pharmacological options were often disappointing: Sulfonylureas and insulin lower blood sugar but caused weight gain, exacerbating the underlying problem
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