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A Mayo Clinic study offers a potential answer by identifying a distinct biological subtype of obesity that responds especially well to tirzepatide, a medication that mimics two naturally occurring hormones involved in appetite and blood sugar regulation, moving the field closer to precision medicine for obesity

The origin of lipedema is not completely understood, although it appears to be associated with hormones

The combination is substantially superior to either componentdemonstrating true complementary mechanism-based additive effects rather than simple additivity

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