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Evidence snapshot: Phase3 studies such as SURMOUNT1 reported average losses exceeding 15%20% at higher doses with supervision
A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria
76,77 The initiation and progression of PCa are linked to complex interactions between acquired somatic gene alterations and microenvironmental factors
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