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We found that nuclear accumulation of DAF-16::GFP was partially but significantly rescued in glp-1(-) and fem-3(-) worms upon RNAi depletion of fat-6/fat-7
Glucagon, a key factor in the pathophysiology of type 2 diabetes
This hormonal cascade alters normal digestive rhythm
The blood pressure-lowering effect appears to be driven primarily by weight loss (patients in the STEP trials lost 10-15% of body weight), though improvements in insulin sensitivity and vascular function may also contribute
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