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doi: 10.21037/atm-21-4162

GLP-1 faces toward TM5 to form cation-pi stacking and hydrogen bond with the rotated down side-chain of R299 ECL2 , while that of W306 5.36b and R310 5.40b switch out from the receptor core to accommodate the approaching of histidine

In the future, the researchers hope to clarify the long-term impact of GLP-1 medications, the HFpEF subpopulations that may derive the most benefit from them, and whether the drugs are also effective in reducing other cardiovascular risks