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Mechanistically, GGsTop treatment led to an accumulation of serum tGSH and a depletion of cysteine in tumours (Fig
Due to the potential for toxicity, solutions containing benzyl alcohol should not be used in neonates
Important safety considerations include the risk of pancreatitis (all GLP-1 agonists carry warnings about this), gallbladder disease (more common with greater weight loss), and a caution with semaglutide in patients with pre-existing diabetic retinopathy, where rapid improvement in glucose control may temporarily worsen retinopathy
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