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B12 deficiency may occur due to poor diet, vegetarian/vegan lifestyle, malabsorption, aging, digestive disorders, or medications like metformin and PPIs

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The authors note that the decrease in leptin is less associated with satiety or subsequent energy intake, likely in part because leptin concentrations do not tend to change until several hours post food intake, with fluctuations more associated with longer-term regulation of energy balance. 4

Potential Retatrutide Side Effects and Management Because Retatrutide influences digestion and blood glucose, current research shows it shares a similar side effect profile with other GLP-1 medications