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Altogether, these findings indicate that the antioxidant effects of metformin are achieved by Nrf2 nuclear translocation, increased downstream cytoplasmic HO-1 expression, and the subsequent activation of Nrf2 dependent signaling pathway
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During a median follow-up of 24 months in the intention-to-treat analysis, 3P-MACE occurred less frequently in the GLP-1RA cohort (HR versus BI 0.59
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