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One potential indirect mechanism involves severe gastrointestinal adverse effects
This implies that, similar to other cardiovascular and metabolic treatments, people cannot discontinue the medication if they wish to maintain their weight loss
[1] [2] In the UK, only specific GLP-1 medications at certain doses are licensed for weight management (liraglutide 3mg and semaglutide 2.4mg), while others are approved solely for type 2 diabetes
The pharmacokinetic case for the 48-hour window Semaglutide's 7-day half-life creates natural forgiveness in the dosing schedule
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