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Stubborn dark spots take a bit longer usually around 2-3 months for significant fading
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for pain relief, are well-established causes of gastric and duodenal ulceration and should be used cautiously in this population
Animal studies repeatedly showed effects involving angiogenesis, collagen organization, and fibroblast migration
The link between this principle and autoimmune diseases was then shown in the 1980s, when Imbach and colleagues found that injection of a large pool of exogenous IgG (IVIg) alleviated idiopathic thrombocytopenia (ITP) [94,95,96]
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