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Tissue Barriers (2016) 4:e1176822
Severe anemia can strain the heart, leading to heart failure
Active or recent malignancy is treated as a hard contraindication in the clinical literature, and a history of hormone-sensitive cancer warrants specialist input
Within these dimers, signaling of the protomers involved are modified through facilitation, inhibition, and even modification of signaling pathways resulting in physiological consequences not seen in the absence of these dimers
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