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SGLT2is, and GLP-1 RAs in particular promote weight loss, and therefore especially may be of benefit, given that overweight and obesity is increasingly prevalent (62%) in individuals with type 1 diabetes [12]
The second enzyme, L-aromatic amino acid decarboxylase (AADC a.k.a
GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection, Nature Communications, 17 , 1, (2026)
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