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Singh, S
The affected enzymes, ERK1/2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, are believed to play significant roles in cell growth, migration, and angiogenesis, which is the development of new blood vessels
NRF2 has also been shown to play an important role in overseeing mitochondrial biogenesis and metabolism, although direct confirmation of target genes involved in these processes has been lacking (Dinkova-Kostova and Abramov, 2015)
Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE Phase 2) screening and recruitment: methods and results
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