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As an initiating factor, mitochondrial DNA mutations or oxidative damage can disrupt respiratory chain function, leading to energy failure and subsequent organ dysfunction [27]
To assess the impact of GSH treatment on OXA-induced ALI, mice (n=10 per group) were treated with OXA (10 mg/kg, i.p.) and GSH (400 mg/kg, i.p., 30 min prior to first OXA injection) for 4 days (once daily until the end of the experiment)
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