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Similarly, Mazahery et al

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Notably, chronic propionate accumulation downregulates cGMP-PKG, reducing contractility and promoting diastolic dysfunction with remodeling risk, particularly in female subjects (Park et al., 2023)

L-Propionylcarnitine (chloride) stimulates energy production in ischemic muscles by increasing citric acid cycle flux and by stimulating pyruvate dehydrogenase activity