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Recent studies show a clear gap between clinical trial results and real-world outcomes for GLP-1 agonists like semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro)

Treatment begins with a 2.5 mg weekly dose for 4 weeks, intended for initiation only, before up-titration in 2.5 mg increments to a maintenance dose of 5-15 mg weekly, depending on individual response and tolerability