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People with certain heart or blood pressure conditions can also be at risk of fluid overload from the infusion

Moreover, a phase 1 study has shown that retatrutide may decrease appetite and increase sensation of fullness and satiety in patients with type 2 diabetes [2]

The plasma UA examination indicated that the HUA model mice showed significantly increased plasma UA levels compared with those of the blank control mice (Figure 5A), which indicated the validity of the animal model