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Use Validated Analytical Methods Ensure all methods are fully validated for accuracy, precision, specificity, and robustness Follow ICH and regulatory guidelines for method validation Regularly review and update methods as technologies evolve 2

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Whats more, its demographic analysis showed significant differences between the GLP-1 RA and comparator groups in factors such as age, HbA1c, body weight, BMI, duration of diabetes, sex, race, and so on, suggesting that the effect of GLP-1RAs on DR is yet controversial and that it may vary based on the specific GLP-1RA used, as well as the patients demographic and clinical characteristics