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And also it is a very good substitute for earlier treatments like NSAIDs because they are very famous to cause gastric irritation

This may lead to impairment of cellular signaling mechanisms and accumulation of misfolded proteins causing proteotoxicity associated with cardiac dysfunction (136143)

Regular liver function tests are recommended during treatment.Cardiovascular Risks: It can affect cholesterol levels (increasing LDL and decreasing HDL), which may raise the risk of atherosclerosis and coronary artery disease

Reported side effects include [1][29]: Flatulence Loose stools Skin rash (rare) Flushing (rare) These side effects have generally been mild and self-limiting