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have observed that PQQ treatment stimulates activation of extracellular signal-regulated kinase 1/2 (ERK 1/2) in c-Ha- ras transformed NIH/3T3 mouse fibroblasts, resulting in increased cell proliferation.Citation 41 ) ERK, one of the mitogen-activated protein kinases, activates transcription in the ras-signaling pathway and plays a pivotal role in cell proliferation and survival.Citation 43 ) This signal transduction by sequential phosphorylation often is initiated by the binding of peptide growth factors to receptor tyrosine kinases (RTKs)

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Vitamin absorption through the bloodstream can be more efficiently utilized by the body, whether by injection into a muscle or infusion directly into the bloodstream

10.1007/s00213-017-4649-y 393