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But glucagon has a powerful secondary effect: it significantly increases energy expenditure in the liver
Essentially, some individuals may end up eating too little, yet still poorly
Purpose-built for physicians Oral GLP-1 reduces body weight, HbA1c for adults with obesity plus type 2 diabetes Key takeaways: All doses of orforglipron conferred greater decreases in weight and HbA1c compared with placebo
While mild to moderate kidney or liver impairment doesn't require dose adjustment, the medication is metabolized gradually throughout the body and eliminated through several routes
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