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(PubMed) Curran JE, Jowett JB, Elliott KS, et al
The authors highlighted mechanism-based combination strategiessuch as pairing HDACis with DNA-damaging agents, kinase inhibitors, immune checkpoint inhibitors, or proteasome inhibitorsthat can enhance antitumor responses and overcome resistance (209)
By enhancing insulin sensitivity in adipose tissue and skeletal muscle, these agents reduce secretion of pro-inflammatory adipokines while concurrently elevating adiponectin an anti-inflammatory hormone whose levels are characteristically suppressed in obesity
A further increase to 2.0 mg once weekly is available if required after at least four weeks at 1.0 mg
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