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Why Injection Delivers Superior Clinical Results Subcutaneous injection places semaglutide directly into the fatty tissue beneath your skin, where it is absorbed steadily into the bloodstream over several hours
In other words, despite producing significantly greater overall weight loss than semaglutide or tirzepatide, retatrutide did not cause a disproportionately higher percentage of muscle loss (Coskun et al., Lancet Diabetes Endocrinol , 2025)
While the therapy did not meet its primary endpoint of progression-free survival, it showed a notable improvement in overall survival: patients receiving IGV-001 had a median overall survival of 20.3 months compared with 14.0 months in the placebo arm, representing a 6.3-month increase
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