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Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

Antioxidants and statins (3-hydroxy-3-methylglutary-coenzyme A reductase inhibitors) A three-year randomized controlled trial in 160 patients with coronary heart disease (CHD) and low high-density-lipoprotein (HDL) levels found that a combination of simvastatin (Zocor) and niacin increased the HDL2 subfraction level (considered the most cardioprotective), inhibited the progression of coronary artery stenosis (narrowing), and decreased the frequency of cardiovascular events, such as myocardial infarction and stroke (130)

Growth hormone therapy in adults works to restore regular body composition, improve muscle and cardiac function, normalize serum lipid concentrations, and improve quality of life

In one recent case report, an ALS patient showed clinical improvement after receiving FMT, with better scores on the ALS Functional Rating Scale and lower levels of inflammation-related markers like CRP and IL-6 (Yan et al., 2024)