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Theres no evidence that combining Ozempic ( semaglutide ) and antidepressants is unsafe, though theres some mixed research on whether antidepressants could diminish the effects of Ozempic or the other way around

Scintigraphic imaging of human volunteers following a single dose of oral semaglutide (10 mg with 300 mg SNAC) demonstrated erosion of the tablet and absorption of semaglutide in the stomach [56]

If you're going to be one of the unlucky ones who has an issue, there's not a way to prevent that from happening to the best of our knowledge as of now, VanderBeek says