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This is where things get critical, and it is something that far too many people overlook
PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction
Results BHBA Treatment Promotes BDNF Expression and Changes Histone H3K4 Trimethylation and Histone H2AK119 Mono-Ubiquitination in Bdnf Promoters Firstly, we verified the increase of BDNF levels in primary hippocampal neurons following treatment with 2 mM BHBA (Figure 1A)
Furthermore, this work offers robust scientific evidence that can inform improved strategies for the prevention and treatment of tissue injury
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