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Interest in such applications is largely driven by their proposed mechanisms of action, including enhancement of tissue repair, modulation of inflammation, and cytoprotective effects observed in preclinical studies
Kashfi K, Rigas B (2005) Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention
The central nervous system (CNS) has uniquely specialized vasculature due to its high metabolic demands and the necessity of tightly controlled transport mechanisms
Given the lack of prior reports demonstrating laccase activity in mammalian systems, we first selected a panel of fungal laccase variants to test in HEK293T cells
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