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Irisin reduces microglia-induced inflammatory responses To investigate whether irisin mitigates microglial activation in MPTP-treated mice, we observed that microglia in the midbrain of MPTP-treated mice exhibited augmented cell size, along with increased branching and more complex morphological features compared to control mice (Fig

Further, such activation may feasibly facilitate the movement of GLUT4 (Glucose Transporter Type 4), a predominant glucose transporter, to the cell surface, potentially promoting the entry of glucose into the cells

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