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As you lose weight with semaglutide, your body's thyroid hormone needs may shift slightly downward because obesity itself worsens insulin resistance and increases inflammationboth of which can mask the true dose required

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5,21 Furthermore, 24 months treatment with the anti-osteoporotic drugs denosumab (Dmab) and alendronate in T2D lead to improvements of bone mineral density (BMD), but Dmab also induced a modest improvement in glycaemic control when compared to alendronate