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Sleep apnoea and type 2 diabetes: additional readouts At the American Diabetes Association Scientific Sessions in June 2026, a sleep apnoea substudy nested within TRIUMPH-1 reported a 60.6 per cent reduction in the apnoea-hypopnoea index from a severe baseline of 58.6 events per hour
Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions
Constipation management Hydration is the foundation
Focal neuropathies, including mononeuropathies and diabetic amyotrophy, present with acute onset pain and weakness in specific nerve distributions
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