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Similarly, bilayer wound dressings , such as asymmetric polycaprolactone (PCL)hydrogel constructs, demonstrate how spatially organized scaffold architectures can facilitate sequential control over hydration, antioxidant release, and tissue regeneration, reinforcing the value of spatiotemporal design principles in regenerative biomaterials [20]

Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig

: bilayer integrity, mechanical strength, swelling and matrix expansion, and layer-specific dissolution all need to be defined deliberately

Although Acetyl-L-Carnitine (ALCAR) is a derivative of an amino acids, it is not itself an amino acid