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Pierro, M., Van Mechelen, K., van Westering-Kroon, E., Villamor-Martnez, E

Broadly speaking, inflammatory macrophages increase production of proinflammatory cytokines IL-6, TNF, IL-1, and type I interferons that create a harmful feedforward immune cell recruitment-activation cycle 2,74,104,105

Neuropsychopharmacology 35(12):24402449 Schroeder JP, Epps SA, Grice TW, Weinshenker D (2013) The selective dopamine -hydroxylase inhibitor nepicastat attenuates multiple aspects of cocaine-seeking behavior

Beyond Month 6: Maintenance Most patients continue at 2.4 milligrams weekly through month 12, when full clinical trial endpoints are typically reached