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Imboden M, Rochat T, Brutsche M, Schindler C, Downs SH, Gerbase MW, et al

When released, it helps regulate your blood sugar by signaling your pancreas to release insulin when needed, while also communicating with areas of your brain that control hunger and fullness

Side Effects Comparison# Retatrutide Side Effects# Phase 2 trial data revealed: Gastrointestinal : Nausea (24-46%), diarrhea (16-26%), vomiting (9-20%), constipation (6-16%) Heart rate : Small mean increase (2-4 bpm) potentially related to glucagon receptor activation Injection site reactions : Mild and transient Hepatic : Transient elevations in liver enzymes observed Discontinuation rate : 6-10% due to adverse events in Phase 2 The glucagon receptor component introduces a unique side effect profile compared to GLP-1-only or GIP/GLP-1 dual agonists

Shah VN, Akturk HK, Kruger D, Ahmann A, Bhargava A, Bakoyannis G, et al