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Conversely, repeated freeze-thaw cycles can damage peptide structure through physical stress to the molecular conformation
Of particular interest are the paracrine effects of adipokines and gastrointestinal substrates regulated by DPP-4, such as leptin, adiponectin, pancreatic peptide YY (PYY), and glucagon-like peptide 1 (GLP-1) and glucagon-like peptide 2 (GLP-2), which may mediate the crosstalk between bone remodeling and energy metabolism [2, 24]
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Medical consensus has shifted firmly toward treating obesity as a chronic condition, which means semaglutide is increasingly viewed as a long-term medication rather than a short-term course
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