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Another study in colonic-sensitized rat models demonstrated that exendin-4 treatment dose-dependently reduced visceral hypersensitivity by upregulating serotonin transporter (SERT) expression and downregulating tryptophan hydroxylase-1 (TPH-1) expression [57]

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7 The research opportunity connecting claims with real-world data The opportunity for manufacturers, researchers, and healthcare stakeholders is to bridge this data gap and gain a comprehensive view of the GLP-1 obesity treatment journey

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