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Monitor for excessive gastrointestinal distress (nausea, vomiting, diarrhoea), significant mood changes or anxiety, unusual fatigue, sleep disturbances, and signs of dehydration
We observed that 11.8% of tirzepatide-treated rs1800437-CC carrier individuals experienced vomiting, compared with 9.4% for semaglutide-treated people carrying the same genotype, although the difference was not significant ( P = 0.12, two-sample z -test
These effects, however, tend to be mild and resolve during the initial weeks of therapy
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