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GLP-1 medications: Stimulate insulin release Act on brain receptors to increase satiety and suppress appetite Slow gastric emptying , making us feel full longer Alter reward pathways , reducing our drive to eat for pleasure rather than hunger [1][3][4] This reward-hacking effect is particularly interesting

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Furthermore, dual drugs exhibit enhanced binding affinity, suggesting their efficacy in inhibiting Pf GR, where the aliphatic ester bond (linker) is essential for effective binding with the enzymes active site